The Church of Santa Agnese in Agone is the most prominent building in Piazza Navona, existing since the eighth century it was built for the worship of Santa Agnese directly where tradition reports that the Holy Child was exposed naked to pillory and occured the prodigious growth of her hair to cover her. Dabartinė išvaizda, kaip ir beveik visa likusi Piazza Navona, yra dėl popiežiaus Inocento X Pamphili, kuris užsakė Carlo ir Girolamo Rainaldi renovuoti visą aikštę, senovinio Domitiano cirko namus.